MovDisordV3, Main, Exploration, bibRecord, 001719

Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

Identifieur interne : 001719 ( Main/Exploration ); précédent : 001718; suivant : 001720

Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

Auteurs : Morvarid Karimi [États-Unis] ; Stephen M. Moerlein [États-Unis] ; Tom O. Videen [États-Unis] ; Robert R. Luedtke [États-Unis] ; Michelle Taylor [États-Unis] ; Robert H. Mach [États-Unis] ; Joel S. Perlmutter [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-01.

RBID : ISTEX:F0D5FF7D1B1CCD484CE50E3FCAE59CB492AB5E74

Descripteurs français

Pascal (Inist)
- Dopamine, Dystonie, Pathologie du système nerveux, Récepteur dopaminergique, Récepteur dopaminergique D2, Récepteur dopaminergique D3, Tomographie par émission de positons, Tomoscintigraphie.

English descriptors

KwdEn :
- Adult, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), D2 Dopamine receptor, D2‐like dopamine receptors, D3 Dopamine receptor, D3 dopamine receptor, Dopamine, Dopamine receptor, Dystonia, Dystonic Disorders (pathology), Dystonic Disorders (radiography), Dystonic Disorders (radionuclide imaging), Emission tomography, Female, Fluorine Radioisotopes (diagnostic use), Humans, Magnetic Resonance Imaging, Male, Middle Aged, NMB, Nervous system diseases, PET, Positron emission tomography, Positron-Emission Tomography, Protein Binding (drug effects), Receptors, Dopamine D2 (metabolism), dopamine, dystonia.
MESH :
- chemical , diagnostic use : Fluorine Radioisotopes.
- drug effects : Protein Binding.
- metabolism : Corpus Striatum, Receptors, Dopamine D2.
- pathology : Dystonic Disorders.
- radiography : Dystonic Disorders.
- radionuclide imaging : Corpus Striatum, Dystonic Disorders.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography.

Abstract

Dystonia is an involuntary movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures. Several lines of evidence suggest that abnormalities of dopaminergic pathways contribute to the pathophysiology of dystonia. In particular, dysfunction of D2‐like receptors that mediate function of the indirect pathway in the basal ganglia may play a key role. We have demonstrated with positron emission tomography that patients with primary focal cranial or hand dystonia have reduced putamenal specific binding of [18F]spiperone, a nonselective D2‐like radioligand with nearly equal affinity for serotonergic 5‐HT(2A) sites. We then repeated the study with [18F]N‐methyl‐benperidol (NMB), a more selective D2‐like receptor radioligand with minimal affinity for 5‐HT(2A). Surprisingly, there was no decrease in NMB binding in the putamen of subjects with dystonia. Our findings excluded reductions of putamenal uptake greater than 20% with 95% confidence intervals. The analysis of the in vitro selectivity of NMB and spiperone demonstrated that NMB was highly selective for D2 receptors relative to D3 receptors (200‐fold difference in affinity), whereas spiperone has similar affinity for all three of the D2‐like receptor subtypes. These findings when coupled with other literature suggest that a defect in D3, rather than D2, receptor expression may be associated with primary focal dystonia. © 2010 Movement Disorder Society.

Url:

DOI: 10.1002/mds.23401

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?</title>
<author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
</author>
<author><name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
</author>
<author><name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
</author>
<author><name sortKey="Luedtke, Robert R" sort="Luedtke, Robert R" uniqKey="Luedtke R" first="Robert R." last="Luedtke">Robert R. Luedtke</name>
</author>
<author><name sortKey="Taylor, Michelle" sort="Taylor, Michelle" uniqKey="Taylor M" first="Michelle" last="Taylor">Michelle Taylor</name>
</author>
<author><name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F0D5FF7D1B1CCD484CE50E3FCAE59CB492AB5E74</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23401</idno>
<idno type="url">https://api.istex.fr/document/F0D5FF7D1B1CCD484CE50E3FCAE59CB492AB5E74/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000837</idno>
<idno type="wicri:Area/Istex/Curation">000837</idno>
<idno type="wicri:Area/Istex/Checkpoint">000452</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Karimi M:decreased:striatal:dopamine</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025272</idno>
<idno type="RBID">PMC:3025272</idno>
<idno type="wicri:Area/Pmc/Corpus">000122</idno>
<idno type="wicri:Area/Pmc/Curation">000122</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000353</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001507</idno>
<idno type="wicri:Area/PubMed/Curation">001507</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001389</idno>
<idno type="wicri:Area/Ncbi/Merge">002F10</idno>
<idno type="wicri:Area/Ncbi/Curation">002F10</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002F10</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Karimi M:decreased:striatal:dopamine</idno>
<idno type="wicri:Area/Main/Merge">001773</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:11-0143221</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000737</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002581</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000644</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Karimi M:decreased:striatal:dopamine</idno>
<idno type="wicri:Area/Main/Merge">001C34</idno>
<idno type="wicri:Area/Main/Curation">001719</idno>
<idno type="wicri:Area/Main/Exploration">001719</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?</title>
<author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Luedtke, Robert R" sort="Luedtke, Robert R" uniqKey="Luedtke R" first="Robert R." last="Luedtke">Robert R. Luedtke</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Michelle" sort="Taylor, Michelle" uniqKey="Taylor M" first="Michelle" last="Taylor">Michelle Taylor</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Occupational Therapy, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Therapy, Washington University School of Medicine, Saint Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-01">2011-01</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="100">100</biblScope>
<biblScope unit="page" to="106">106</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">F0D5FF7D1B1CCD484CE50E3FCAE59CB492AB5E74</idno>
<idno type="DOI">10.1002/mds.23401</idno>
<idno type="ArticleID">MDS23401</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>D2 Dopamine receptor</term>
<term>D2‐like dopamine receptors</term>
<term>D3 Dopamine receptor</term>
<term>D3 dopamine receptor</term>
<term>Dopamine</term>
<term>Dopamine receptor</term>
<term>Dystonia</term>
<term>Dystonic Disorders (pathology)</term>
<term>Dystonic Disorders (radiography)</term>
<term>Dystonic Disorders (radionuclide imaging)</term>
<term>Emission tomography</term>
<term>Female</term>
<term>Fluorine Radioisotopes (diagnostic use)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>NMB</term>
<term>Nervous system diseases</term>
<term>PET</term>
<term>Positron emission tomography</term>
<term>Positron-Emission Tomography</term>
<term>Protein Binding (drug effects)</term>
<term>Receptors, Dopamine D2 (metabolism)</term>
<term>dopamine</term>
<term>dystonia</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorine Radioisotopes</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Protein Binding</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Dystonic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term>
<term>Dystonic Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term>
<term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Récepteur dopaminergique</term>
<term>Récepteur dopaminergique D2</term>
<term>Récepteur dopaminergique D3</term>
<term>Tomographie par émission de positons</term>
<term>Tomoscintigraphie</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Dystonia is an involuntary movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures. Several lines of evidence suggest that abnormalities of dopaminergic pathways contribute to the pathophysiology of dystonia. In particular, dysfunction of D2‐like receptors that mediate function of the indirect pathway in the basal ganglia may play a key role. We have demonstrated with positron emission tomography that patients with primary focal cranial or hand dystonia have reduced putamenal specific binding of [18F]spiperone, a nonselective D2‐like radioligand with nearly equal affinity for serotonergic 5‐HT(2A) sites. We then repeated the study with [18F]N‐methyl‐benperidol (NMB), a more selective D2‐like receptor radioligand with minimal affinity for 5‐HT(2A). Surprisingly, there was no decrease in NMB binding in the putamen of subjects with dystonia. Our findings excluded reductions of putamenal uptake greater than 20% with 95% confidence intervals. The analysis of the in vitro selectivity of NMB and spiperone demonstrated that NMB was highly selective for D2 receptors relative to D3 receptors (200‐fold difference in affinity), whereas spiperone has similar affinity for all three of the D2‐like receptor subtypes. These findings when coupled with other literature suggest that a defect in D3, rather than D2, receptor expression may be associated with primary focal dystonia. © 2010 Movement Disorder Society.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Missouri (État)</li>
<li>Texas</li>
</region>
<settlement><li>Saint-Louis (Missouri)</li>
</settlement>
<orgName><li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
</region>
<name sortKey="Luedtke, Robert R" sort="Luedtke, Robert R" uniqKey="Luedtke R" first="Robert R." last="Luedtke">Robert R. Luedtke</name>
<name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Taylor, Michelle" sort="Taylor, Michelle" uniqKey="Taylor M" first="Michelle" last="Taylor">Michelle Taylor</name>
<name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
<name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001719 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001719 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:F0D5FF7D1B1CCD484CE50E3FCAE59CB492AB5E74
   |texte=   Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.